Intravenous administration of Escherichia coli endotoxin at a dose of 0.05 μg/kg bodyweight to pregnant camels resulted in abortion. The injection of endotoxin caused significant increases in the plasma concentration of 13,14-dihydro-15-prostaglandin F2α, the metabolite of prostaglandin F2α (PG F2α) and cortisol and a significant decrease in the concentration of progesterone. It is suggested th...

Isoprostanes are stable products of arachidonic acid peroxidation and are regarded as the most reliable markers of oxidative stress in vivo. Here we describe the LC-MS/MS procedure enabling simultaneous determination of four regioisomers (8-iso prostaglandin F2α, 8-iso-15(R)-prostaglandin F2α, 11β-prostaglandin F2α, 15(R)-prostaglandin F2α) in plasma samples collected from mice. The four plasma...

Prostaglandin F2α analogs, commonly prescribed for glaucoma treatment, have been shown to induce side effects such as cutaneous hypertrichosis and hyperpigmentation. Therefore, these medications have theoretic applications in the treatment of alopecia and disorders of hypopigmentation. We reviewed the literature to find original studies assessing the use of prostaglandin F2α analogs in these se...

the aim of this study was to analyze the incidence of stage of embryonic development, embryo quality and the time of transfer on pregnancy rate in embryo transfer program timed. we were worked a total of 23holsteincowsasembryo donors, super-ovulated with gonadotropin of pregnant mare serum (pmsg) (2500 3000ui).69 cows were used as recipients of holstein dairy heifers with an age of20 months and...

the purpose of present study is testing influence of injection oxytocin immediately after parturition and injection prostaglandin f2α, 20 to 25 days after parturition in dairy cows upon process of uterus contraction distance between delivery till first estrus distance between parturition till first and second semenation, amount of pregnancy at first semenation and number of semenation for every...

Prostamide (prostaglandin ethanolamide) research emerged from two distinct lines of research: 1) the unique pharmacology of the antiglaucoma drug bimatoprost and 2) the discovery that endocannabinoid anandamide was converted by COX-2 to a series of electrochemically neutral prostaglandin (PG) ethanolamides. Bimatoprost pharmacology was found to be virtually identical to that of prostamide F2α. ...

Södergren, E. 2000. Lipid peroxidation in vivo. Evaluation and application of methods for measurement. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 949. 78 pp. Uppsala. ISBN 91-554-4791-0. Lipid peroxidation is thought to be an important factor in the pathophysiology of a number of diseases and in the process of ageing, but its me...

LutaLyse® Injection (dinoprost injection) is the most-researched, most-recommended, and most-used prostaglandin that cattle producers and veterinarians have trusted for more than 35 years. Dinoprost, the active ingredient of LutaLyse, is the naturally occurring prostaglandin F2α (PGF2α) that can help producers control breeding, improve pregnancy rates, reduce reproductive culls, reduce time nec...

OBJECTIVE Type 1 diabetes is associated with increased platelet reactivity. We investigated whether α-lipoic acid (ALA) has any effect on platelet reactivity in these patients. RESEARCH DESIGN AND METHODS We randomly assigned 51 type 1 diabetic patients to ALA (600 mg once daily) or placebo for 5 weeks. Platelet reactivity was evaluated by the PFA-100 method and by measuring CD41 and CD62 pla...